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KMID : 1004820090100020087
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Journal of Biomedical Research
2009 Volume.10 No. 2 p.87 ~ p.95
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Augmentation by Hypercholesterolemia of Amyloid β Peptide-Induced Learning and Memory Deficit
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Park Dong-Sun
Oh Ji-Young
Kim Tae-Kyun
Cho Young-Jin
Lee Sun-Hee
Bae Dae-Kwon
Yang Yun-Hui
Yang Go-Eun
Hwang Seock-Yeon
Kim Yun-Bae
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Abstract
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The present study was carried out to establish an animal model, displaying long-term learningand memory dysfunction, since single intracerebroventricular (icv) injection of amyloid β peptide (Aβ) causesa short-term memory impairment. Male ICR mice were fed a high-cholesterol diet (HCD) containing 3%cholesterol, 1% corn oil and 0.5% cholic acid, and 1 week later, icv injected with Aβ1-42 (5 μg/head). Learning/memory function was assessed via passive avoidance performances 1 day and 2, 4, and 6 weeks after Aβ1-42injection, in addition to blood biochemical analyses for lipid profiles and hepatic function. Total cholesterol, lowdensitylipoproteins and hepatic dysfunction parameters markedly increased, while high-density lipoproteinswere reduced following HCD feeding. Whereas single injection of Aβ induced temporary memory loss 1 dayafter administration, exhibiting full recovery after 2 weeks, Aβ treatment in combination with HCD feedinglasted the learning/memory impairment up to 6 weeks. Therefore, it is suggested that hypercholesterolemiaaugments Aβ-induced memory loss, and that Aβ injection plus HCD feeding could be a long-term memorydeficitmodel suitable for long-term treatment with drugs or stem cells.
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KEYWORD
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Alzheimer disease, Amyloid β peptide (Aβ), Memory deficit, Hypercholesterolemia
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